BindingDB PrimarySearch

Found 12 hits Enz. Inhib. hit(s) with Target = 'Phospholipase D1' and Ligand = 'BDBM87245'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Phospholipase D1 (Homo sapiens (Human))	BDBM87245 (CHEMBL492797 \| ML272 \| N-(2-(4-(2-Oxo-2,3-dihydro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt Specialized Chemistry Center Curated by PubChem BioAssay					Assay Description Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2NK3CNK
					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87245 (CHEMBL492797 \| ML272 \| N-(2-(4-(2-Oxo-2,3-dihydro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of human PLD1 in Calu1 cells				Bioorg Med Chem Lett 19: 1916-20 (2009) Article DOI: 10.1016/j.bmcl.2009.02.057 BindingDB Entry DOI: 10.7270/Q2VM4C5W
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87245 (CHEMBL492797 \| ML272 \| N-(2-(4-(2-Oxo-2,3-dihydro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description The ability of representative disclosed to block influenza infection was assessed in a cell-based assay using A549 human epithelial cells (ATCC CCL-1...				US Patent US9453017 (2016) BindingDB Entry DOI: 10.7270/Q29K495R
Vanderbilt University US Patent					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87245 (CHEMBL492797 \| ML272 \| N-(2-(4-(2-Oxo-2,3-dihydro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University					Assay Description Cells were seeded into 12-well tissue culture plates to reach 90% confluence at the time of assay. All cell types, aside from the HEK293-gfpPLD2 cell...				ACS Chem Biol 10: 421-32 (2015) Article DOI: 10.1021/cb500828m BindingDB Entry DOI: 10.7270/Q2H70DK8
Vanderbilt University					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87245 (CHEMBL492797 \| ML272 \| N-(2-(4-(2-Oxo-2,3-dihydro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description In vitro PLD activity is measured with an exogenous substrate assay as previously described (Brown, H. A. et al. (1993) Cell 75:1137-1144). Briefly, ...				US Patent US9453017 (2016) BindingDB Entry DOI: 10.7270/Q29K495R
Vanderbilt University US Patent					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87245 (CHEMBL492797 \| ML272 \| N-(2-(4-(2-Oxo-2,3-dihydro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	37
Vanderbilt University					Assay Description PLD in vitro enzymatic assay using phospholipase D1(PLD1).				Nat Chem Biol 5: 108-17 (2009) Article DOI: 10.1038/nchembio.140 BindingDB Entry DOI: 10.7270/Q2D50KBK
Vanderbilt University					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87245 (CHEMBL492797 \| ML272 \| N-(2-(4-(2-Oxo-2,3-dihydro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt Specialized Chemistry Center Curated by PubChem BioAssay					Assay Description Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2SB44BV
					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87245 (CHEMBL492797 \| ML272 \| N-(2-(4-(2-Oxo-2,3-dihydro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	37
Vanderbilt University					Assay Description PLD in vitro enzymatic assay using phospholipase D2(PLD2).				Nat Chem Biol 5: 108-17 (2009) Article DOI: 10.1038/nchembio.140 BindingDB Entry DOI: 10.7270/Q2D50KBK
Vanderbilt University					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87245 (CHEMBL492797 \| ML272 \| N-(2-(4-(2-Oxo-2,3-dihydro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	255	n/a	n/a	n/a	n/a	n/a	37
University of Massachusetts Boston					Assay Description PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions...				Chem Biol Drug Des 84: 270-81 (2014) Article DOI: 10.1111/cbdd.12319 BindingDB Entry DOI: 10.7270/Q2HT2N05
University of Massachusetts Boston					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87245 (CHEMBL492797 \| ML272 \| N-(2-(4-(2-Oxo-2,3-dihydro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Vanderbilt University					Assay Description Phopholipase D1(PLD)enzymatic inhibition assay using PLD1.d311				Nat Chem Biol 5: 108-17 (2009) Article DOI: 10.1038/nchembio.140 BindingDB Entry DOI: 10.7270/Q2D50KBK
Vanderbilt University					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87245 (CHEMBL492797 \| ML272 \| N-(2-(4-(2-Oxo-2,3-dihydro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	21	n/a	n/a	n/a	37
Vanderbilt University					Assay Description cell-based assay using human non-small-cell lung cancer cell line, Calu-1				Nat Chem Biol 5: 108-17 (2009) Article DOI: 10.1038/nchembio.140 BindingDB Entry DOI: 10.7270/Q2D50KBK
Vanderbilt University					More data for this Ligand-Target Pair
Phospholipase D1 (Homo sapiens (Human))	BDBM87245 (CHEMBL492797 \| ML272 \| N-(2-(4-(2-Oxo-2,3-dihydro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	380	n/a	n/a	n/a	37
Vanderbilt University					Assay Description cell-based assay using HEK293-gfpPLD2 cell line				Nat Chem Biol 5: 108-17 (2009) Article DOI: 10.1038/nchembio.140 BindingDB Entry DOI: 10.7270/Q2D50KBK
Vanderbilt University					More data for this Ligand-Target Pair