Found 2 hits Enz. Inhib. hit(s) with Target = 'Placenta growth factor' and Ligand = 'BDBM50339210' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339210
(CHEMBL1689481)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(C)C |r,wU:39.41,4.3,64.68,49.56,2.2,145.161,161.170,106.112,132.140,20.21,8.8,wD:56.60,100.108,117.123,156.165,99.105,136.149,35.102,30.136,166.179,(33.81,-1.12,;32.48,-1.89,;31.15,-1.12,;31.14,.41,;29.82,-1.9,;25.88,-4.17,;24.55,-3.39,;23.21,-4.14,;24.57,-1.86,;25.89,-1.11,;25.92,.43,;27.25,1.17,;27.26,2.71,;25.95,3.49,;25.97,5.03,;24.61,2.74,;24.59,1.21,;23.24,-1.06,;21.91,-1.82,;21.89,-3.36,;20.57,-1.03,;20.59,.5,;19.27,1.29,;19.13,2.81,;17.63,3.15,;16.84,1.83,;17.85,.68,;19.23,-1.81,;19.29,-3.29,;20.64,-4.03,;17.93,-4.05,;17.92,-5.6,;19.26,-6.41,;19.25,-7.97,;20.56,-8.79,;20.56,-10.33,;21.88,-11.11,;21.88,-12.65,;20.55,-13.41,;23.2,-13.41,;23.19,-14.96,;21.85,-15.72,;20.45,-15.09,;19.42,-16.23,;20.19,-17.57,;21.7,-17.25,;24.54,-12.66,;25.85,-13.43,;25.84,-14.96,;27.2,-12.66,;28.65,-13.14,;29.56,-11.91,;28.66,-10.66,;27.2,-11.13,;25.86,-10.38,;24.54,-11.14,;25.86,-8.84,;24.53,-8.08,;23.2,-8.85,;21.86,-8.09,;23.2,-10.39,;27.19,-8.06,;27.18,-6.53,;25.84,-5.77,;28.51,-5.75,;29.84,-6.52,;29.83,-8.06,;31.15,-8.83,;31.15,-10.39,;32.49,-11.17,;33.85,-10.39,;33.85,-8.84,;35.19,-11.18,;36.54,-10.4,;37.88,-11.18,;39.24,-10.41,;39.24,-8.85,;40.58,-11.19,;41.93,-10.41,;43.27,-11.2,;44.62,-10.43,;44.63,-8.87,;45.98,-8.09,;47.32,-8.87,;48.67,-8.1,;48.67,-6.54,;50.02,-8.88,;50.41,-10.38,;51.92,-9.97,;51.52,-8.47,;52.3,-7.13,;43.27,-8.09,;41.93,-8.87,;28.54,-4.2,;29.83,-3.45,;31.16,-4.2,;19.22,-11.1,;19.22,-12.63,;17.9,-10.34,;16.57,-11.1,;16.57,-12.63,;15.24,-13.41,;17.9,-13.4,;15.24,-10.32,;15.24,-8.79,;13.9,-11.1,;12.57,-10.32,;12.56,-8.79,;11.22,-8.02,;9.9,-8.79,;8.57,-8.03,;7.24,-8.8,;5.92,-8.03,;7.24,-10.33,;11.22,-11.1,;9.9,-10.34,;11.23,-12.63,;9.92,-13.4,;9.92,-14.96,;8.58,-15.74,;7.23,-14.97,;5.89,-15.75,;5.89,-17.31,;4.55,-18.09,;7.25,-18.08,;8.59,-17.29,;8.58,-12.64,;7.24,-13.42,;8.58,-11.11,;16.61,-3.28,;15.27,-4.03,;15.27,-5.57,;13.93,-3.28,;12.58,-4.05,;11.27,-3.29,;11.27,-1.76,;9.92,-4.07,;9.94,-5.6,;8.61,-6.38,;7.27,-5.63,;5.97,-6.41,;7.26,-4.1,;8.62,-3.3,;8.62,-1.77,;9.95,-1,;7.29,-.99,;7.3,.54,;8.64,1.3,;9.96,.53,;11.29,1.29,;11.31,2.83,;9.97,3.6,;8.64,2.83,;5.96,-1.75,;4.63,-.98,;4.63,.57,;3.29,-1.75,;3.29,-3.3,;1.95,-.98,;.62,-1.75,;.62,-3.3,;-.72,-.98,;-.72,.57,;-2.05,-1.75,;-3.39,-.98,;-3.39,.57,;-4.73,-1.75,;-4.73,-3.3,;-3.39,-4.07,;-2.05,-3.3,;-3.39,-5.62,;-6.07,-.98,;-7.4,-1.76,;-8.73,-.99,;-7.4,-3.3,;13.92,-1.75,;12.58,-.97,;15.25,-.97,)| Show InChI InChI=1S/C116H161N29O31S2/c1-11-62(6)96-113(173)131-76(21-15-16-41-122-89(150)54-176-55-90(151)129-71-31-24-67(25-32-71)30-38-91(152)145-44-40-92(145)153)102(162)138-85(45-60(2)3)115(175)144-43-18-23-88(144)111(171)137-83(50-73-53-121-59-125-73)107(167)139-87(110(170)143-97(65(9)146)114(174)132-77(22-17-42-123-116(118)119)101(161)133-79(98(117)158)46-69-26-33-74(148)34-27-69)57-178-177-56-86(109(169)136-82(49-72-52-120-58-124-72)106(166)135-81(108(168)142-96)48-70-28-35-75(149)36-29-70)140-112(172)95(61(4)5)141-103(163)78(37-39-93(154)155)130-105(165)80(47-68-19-13-12-14-20-68)134-100(160)64(8)126-99(159)63(7)127-104(164)84(51-94(156)157)128-66(10)147/h12-14,19-20,24-29,31-36,52-53,58-65,76-88,95-97,146,148-149H,11,15-18,21-23,30,37-51,54-57H2,1-10H3,(H2,117,158)(H,120,124)(H,121,125)(H,122,150)(H,126,159)(H,127,164)(H,128,147)(H,129,151)(H,130,165)(H,131,173)(H,132,174)(H,133,161)(H,134,160)(H,135,166)(H,136,169)(H,137,171)(H,138,162)(H,139,167)(H,140,172)(H,141,163)(H,142,168)(H,143,170)(H,154,155)(H,156,157)(H4,118,119,123)/t62-,63-,64-,65+,76-,77+,78-,79+,80-,81-,82-,83-,84-,85-,86-,87-,88-,95-,96-,97+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339210
(CHEMBL1689481)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(C)C |r,wU:39.41,4.3,64.68,49.56,2.2,145.161,161.170,106.112,132.140,20.21,8.8,wD:56.60,100.108,117.123,156.165,99.105,136.149,35.102,30.136,166.179,(33.81,-1.12,;32.48,-1.89,;31.15,-1.12,;31.14,.41,;29.82,-1.9,;25.88,-4.17,;24.55,-3.39,;23.21,-4.14,;24.57,-1.86,;25.89,-1.11,;25.92,.43,;27.25,1.17,;27.26,2.71,;25.95,3.49,;25.97,5.03,;24.61,2.74,;24.59,1.21,;23.24,-1.06,;21.91,-1.82,;21.89,-3.36,;20.57,-1.03,;20.59,.5,;19.27,1.29,;19.13,2.81,;17.63,3.15,;16.84,1.83,;17.85,.68,;19.23,-1.81,;19.29,-3.29,;20.64,-4.03,;17.93,-4.05,;17.92,-5.6,;19.26,-6.41,;19.25,-7.97,;20.56,-8.79,;20.56,-10.33,;21.88,-11.11,;21.88,-12.65,;20.55,-13.41,;23.2,-13.41,;23.19,-14.96,;21.85,-15.72,;20.45,-15.09,;19.42,-16.23,;20.19,-17.57,;21.7,-17.25,;24.54,-12.66,;25.85,-13.43,;25.84,-14.96,;27.2,-12.66,;28.65,-13.14,;29.56,-11.91,;28.66,-10.66,;27.2,-11.13,;25.86,-10.38,;24.54,-11.14,;25.86,-8.84,;24.53,-8.08,;23.2,-8.85,;21.86,-8.09,;23.2,-10.39,;27.19,-8.06,;27.18,-6.53,;25.84,-5.77,;28.51,-5.75,;29.84,-6.52,;29.83,-8.06,;31.15,-8.83,;31.15,-10.39,;32.49,-11.17,;33.85,-10.39,;33.85,-8.84,;35.19,-11.18,;36.54,-10.4,;37.88,-11.18,;39.24,-10.41,;39.24,-8.85,;40.58,-11.19,;41.93,-10.41,;43.27,-11.2,;44.62,-10.43,;44.63,-8.87,;45.98,-8.09,;47.32,-8.87,;48.67,-8.1,;48.67,-6.54,;50.02,-8.88,;50.41,-10.38,;51.92,-9.97,;51.52,-8.47,;52.3,-7.13,;43.27,-8.09,;41.93,-8.87,;28.54,-4.2,;29.83,-3.45,;31.16,-4.2,;19.22,-11.1,;19.22,-12.63,;17.9,-10.34,;16.57,-11.1,;16.57,-12.63,;15.24,-13.41,;17.9,-13.4,;15.24,-10.32,;15.24,-8.79,;13.9,-11.1,;12.57,-10.32,;12.56,-8.79,;11.22,-8.02,;9.9,-8.79,;8.57,-8.03,;7.24,-8.8,;5.92,-8.03,;7.24,-10.33,;11.22,-11.1,;9.9,-10.34,;11.23,-12.63,;9.92,-13.4,;9.92,-14.96,;8.58,-15.74,;7.23,-14.97,;5.89,-15.75,;5.89,-17.31,;4.55,-18.09,;7.25,-18.08,;8.59,-17.29,;8.58,-12.64,;7.24,-13.42,;8.58,-11.11,;16.61,-3.28,;15.27,-4.03,;15.27,-5.57,;13.93,-3.28,;12.58,-4.05,;11.27,-3.29,;11.27,-1.76,;9.92,-4.07,;9.94,-5.6,;8.61,-6.38,;7.27,-5.63,;5.97,-6.41,;7.26,-4.1,;8.62,-3.3,;8.62,-1.77,;9.95,-1,;7.29,-.99,;7.3,.54,;8.64,1.3,;9.96,.53,;11.29,1.29,;11.31,2.83,;9.97,3.6,;8.64,2.83,;5.96,-1.75,;4.63,-.98,;4.63,.57,;3.29,-1.75,;3.29,-3.3,;1.95,-.98,;.62,-1.75,;.62,-3.3,;-.72,-.98,;-.72,.57,;-2.05,-1.75,;-3.39,-.98,;-3.39,.57,;-4.73,-1.75,;-4.73,-3.3,;-3.39,-4.07,;-2.05,-3.3,;-3.39,-5.62,;-6.07,-.98,;-7.4,-1.76,;-8.73,-.99,;-7.4,-3.3,;13.92,-1.75,;12.58,-.97,;15.25,-.97,)| Show InChI InChI=1S/C116H161N29O31S2/c1-11-62(6)96-113(173)131-76(21-15-16-41-122-89(150)54-176-55-90(151)129-71-31-24-67(25-32-71)30-38-91(152)145-44-40-92(145)153)102(162)138-85(45-60(2)3)115(175)144-43-18-23-88(144)111(171)137-83(50-73-53-121-59-125-73)107(167)139-87(110(170)143-97(65(9)146)114(174)132-77(22-17-42-123-116(118)119)101(161)133-79(98(117)158)46-69-26-33-74(148)34-27-69)57-178-177-56-86(109(169)136-82(49-72-52-120-58-124-72)106(166)135-81(108(168)142-96)48-70-28-35-75(149)36-29-70)140-112(172)95(61(4)5)141-103(163)78(37-39-93(154)155)130-105(165)80(47-68-19-13-12-14-20-68)134-100(160)64(8)126-99(159)63(7)127-104(164)84(51-94(156)157)128-66(10)147/h12-14,19-20,24-29,31-36,52-53,58-65,76-88,95-97,146,148-149H,11,15-18,21-23,30,37-51,54-57H2,1-10H3,(H2,117,158)(H,120,124)(H,121,125)(H,122,150)(H,126,159)(H,127,164)(H,128,147)(H,129,151)(H,130,165)(H,131,173)(H,132,174)(H,133,161)(H,134,160)(H,135,166)(H,136,169)(H,137,171)(H,138,162)(H,139,167)(H,140,172)(H,141,163)(H,142,168)(H,143,170)(H,154,155)(H,156,157)(H4,118,119,123)/t62-,63-,64-,65+,76-,77+,78-,79+,80-,81-,82-,83-,84-,85-,86-,87-,88-,95-,96-,97+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human PlGF-1 |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
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