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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Placenta growth factor' and Ligand = 'BDBM50339215'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Placenta growth factor


(Homo sapiens (Human))		BDBM50339215
PNG
(CHEMBL1689457)
Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(N)=O |r|
Show InChI InChI=1S/C83H123N21O20S3/c1-41(2)30-59-83(124)104-28-19-25-62(104)78(119)96-56(33-49-37-87-40-89-49)72(113)98-60(76(117)92-53(24-17-18-27-84)70(111)100-65(42(3)4)79(120)91-52(69(86)110)26-29-125-11)38-126-127-39-61(99-80(121)66(43(5)6)101-75(116)58(35-64(108)109)95-71(112)54(90-46(10)106)31-47-20-13-12-14-21-47)77(118)94-57(34-63(85)107)73(114)93-55(32-48-36-88-51-23-16-15-22-50(48)51)74(115)102-67(44(7)8)81(122)103-68(45(9)105)82(123)97-59/h12-16,20-23,36-37,40-45,52-62,65-68,88,105H,17-19,24-35,38-39,84H2,1-11H3,(H2,85,107)(H2,86,110)(H,87,89)(H,90,106)(H,91,120)(H,92,117)(H,93,114)(H,94,118)(H,95,112)(H,96,119)(H,97,123)(H,98,113)(H,99,121)(H,100,111)(H,101,116)(H,102,115)(H,103,122)(H,108,109)/t45-,52+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,65+,66+,67+,68+/m1/s1
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Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA

J Med Chem 54: 1256-65 (2011)


Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1
More data for this
Ligand-Target Pair