Found 2 hits Enz. Inhib. hit(s) with Target = 'Platelet-activating factor receptor' and Ligand = 'BDBM50284416' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50284416
(2-{[Acetyl-(3-octadecylcarbamoyloxymethyl-cyclobut...)Show SMILES CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 |wU:23.22,wD:25.25,(-6.84,-45.17,;-6.14,-43.8,;-4.61,-43.71,;-3.91,-42.33,;-2.38,-42.25,;-1.69,-40.87,;-.16,-40.79,;.54,-39.42,;2.07,-39.33,;2.77,-37.95,;4.29,-37.87,;4.99,-36.49,;6.53,-36.41,;7.21,-35.04,;8.76,-34.95,;9.44,-33.57,;10.98,-33.49,;11.68,-32.11,;13.22,-32.03,;13.91,-30.66,;13.05,-29.38,;15.45,-30.57,;16.28,-31.86,;17.82,-31.78,;18.83,-30.62,;20,-31.66,;21.53,-31.57,;22.23,-30.2,;23.76,-30.11,;24.6,-31.4,;24.45,-28.75,;25.98,-28.66,;26.82,-29.94,;26.12,-31.31,;26.96,-32.59,;28.5,-32.52,;29.2,-31.15,;28.36,-29.85,;29.05,-28.48,;30.59,-28.4,;23.61,-27.45,;22.07,-27.54,;24.31,-26.08,;18.97,-32.8,)| Show InChI InChI=1S/C36H61N3O5/c1-4-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-24-37-35(41)43-29-32-26-33(27-32)30-44-36(42)39(31(3)40)28-34-23-20-22-25-38(34)5-2/h20,22-23,25,32-33H,4-19,21,24,26-30H2,1-3H3/p+1/t32-,33- | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| 4.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro ability to displace [3H]-PAF from PAF receptor in rabbit platelet membranes |
Bioorg Med Chem Lett 5: 1097-1102 (1995)
Article DOI: 10.1016/0960-894X(95)00174-R BindingDB Entry DOI: 10.7270/Q2NZ87KQ |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(Cavia porcellus) | BDBM50284416
(2-{[Acetyl-(3-octadecylcarbamoyloxymethyl-cyclobut...)Show SMILES CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 |wU:23.22,wD:25.25,(-6.84,-45.17,;-6.14,-43.8,;-4.61,-43.71,;-3.91,-42.33,;-2.38,-42.25,;-1.69,-40.87,;-.16,-40.79,;.54,-39.42,;2.07,-39.33,;2.77,-37.95,;4.29,-37.87,;4.99,-36.49,;6.53,-36.41,;7.21,-35.04,;8.76,-34.95,;9.44,-33.57,;10.98,-33.49,;11.68,-32.11,;13.22,-32.03,;13.91,-30.66,;13.05,-29.38,;15.45,-30.57,;16.28,-31.86,;17.82,-31.78,;18.83,-30.62,;20,-31.66,;21.53,-31.57,;22.23,-30.2,;23.76,-30.11,;24.6,-31.4,;24.45,-28.75,;25.98,-28.66,;26.82,-29.94,;26.12,-31.31,;26.96,-32.59,;28.5,-32.52,;29.2,-31.15,;28.36,-29.85,;29.05,-28.48,;30.59,-28.4,;23.61,-27.45,;22.07,-27.54,;24.31,-26.08,;18.97,-32.8,)| Show InChI InChI=1S/C36H61N3O5/c1-4-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-24-37-35(41)43-29-32-26-33(27-32)30-44-36(42)39(31(3)40)28-34-23-20-22-25-38(34)5-2/h20,22-23,25,32-33H,4-19,21,24,26-30H2,1-3H3/p+1/t32-,33- | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets |
Bioorg Med Chem Lett 5: 1097-1102 (1995)
Article DOI: 10.1016/0960-894X(95)00174-R BindingDB Entry DOI: 10.7270/Q2NZ87KQ |
More data for this Ligand-Target Pair | |