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Found 1 hit Enz. Inhib. hit(s) with Target = 'Platelet-derived growth factor receptor alpha [D842V]' and Ligand = 'BDBM469232'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Platelet-derived growth factor receptor alpha [D842V]


(Homo sapiens (Human))		BDBM469232
PNG
(US10807985, Compound 7)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1
Show InChI InChI=1S/C25H25N9/c1-31-16-22(15-29-31)21-12-23-24(28-18-30-34(23)17-21)32-7-9-33(10-8-32)25-26-13-20(14-27-25)11-19-5-3-2-4-6-19/h2-6,12-18H,7-11H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
In each well of a 384-well plate, 0.7 ng/ul (8 nM) of PDGFRA D842V (ProQinase 0761-0000-1) was incubated in a total of 12.5 ul of buffer (100 mM HEPE...

US Patent US10807985 (2020)


BindingDB Entry DOI: 10.7270/Q2F76GNN
More data for this
Ligand-Target Pair