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Found 1 hit Enz. Inhib. hit(s) with Target = 'Poly [ADP-ribose] polymerase 1' and Ligand = 'BDBM50296558'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM50296558
PNG
(CHEMBL560133 | N-(2-(6-oxo-6,7,8,9-tetrahydro-3H-p...)
Show SMILES O=C(NCCc1c[nH]c2ccc3C(=O)NCCc3c12)c1ccccn1
Show InChI InChI=1S/C19H18N4O2/c24-18-14-4-5-15-17(13(14)7-10-21-18)12(11-23-15)6-9-22-19(25)16-3-1-2-8-20-16/h1-5,8,11,23H,6-7,9-10H2,(H,21,24)(H,22,25)
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PC cid
PC sid
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Similars
Article
PubMed
n/an/a 44n/an/an/an/an/an/a



IRBM--Merck Research Laboratories Rome

Curated by ChEMBL


Assay Description
Inhibition of PARP1 in human HeLa cells by microplate scintillation counting

Bioorg Med Chem Lett 19: 4042-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.031
BindingDB Entry DOI: 10.7270/Q2WH2Q09
More data for this
Ligand-Target Pair