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Found 1 hit Enz. Inhib. hit(s) with Target = 'Polycomb protein EED' and Ligand = 'BDBM50235991'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Polycomb protein EED


(Homo sapiens (Human))
BDBM50235991
PNG
(CHEMBL4105039)
Show SMILES C(Nc1ncc(-c2ccccc2)c2nncn12)c1ccco1
Show InChI InChI=1S/C16H13N5O/c1-2-5-12(6-3-1)14-10-18-16(21-11-19-20-15(14)21)17-9-13-7-4-8-22-13/h1-8,10-11H,9H2,(H,17,18)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 52n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of EED in human G401 cells assessed as reduction in global H3K27me3 level after 48 hrs by ELISA


J Med Chem 60: 2215-2226 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01576
BindingDB Entry DOI: 10.7270/Q20G3NDT
More data for this
Ligand-Target Pair