Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Polymerase basic protein 2' and Ligand = 'BDBM50507225'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50507225 (CHEMBL4444973) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(nc2c(csc12)C#N)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(68.54,-43.82,;69.88,-44.58,;71.22,-43.8,;69.89,-46.12,;71.24,-46.89,;71.25,-48.44,;69.92,-49.22,;68.58,-48.46,;69.35,-47.16,;70.46,-48.07,;68.58,-46.91,;67.24,-46.16,;65.93,-46.93,;66.41,-48.38,;65.39,-49.52,;63.89,-49.22,;63.4,-47.77,;61.99,-47.14,;62.16,-45.61,;63.66,-45.29,;64.43,-46.62,;60.67,-47.9,;59.35,-48.67,;65.87,-50.97,;64.97,-52.23,;65.88,-53.48,;67.35,-52.99,;68.69,-53.76,;70.02,-52.99,;70.02,-51.44,;71.35,-50.66,;68.68,-50.67,;67.34,-51.45,)| Show InChI InChI=1S/C23H19FN6O2S/c24-13-5-14-15(8-27-20(14)26-7-13)21-29-18-12(6-25)9-33-19(18)22(30-21)28-17-11-3-1-10(2-4-11)16(17)23(31)32/h5,7-11,16-17H,1-4H2,(H,26,27)(H,31,32)(H,28,29,30)/t10?,11?,16-,17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
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