Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Polymerase basic protein 2' and Ligand = 'BDBM50507227'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50507227 (CHEMBL4519832) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(nc2CS(=O)(=O)Cc12)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(22.98,-2.34,;24.32,-3.1,;25.65,-2.32,;24.33,-4.65,;25.68,-5.41,;25.69,-6.96,;24.35,-7.74,;23.02,-6.98,;23.78,-5.69,;24.9,-6.59,;23.02,-5.43,;21.68,-4.68,;20.37,-5.46,;20.85,-6.91,;19.83,-8.04,;18.32,-7.75,;17.84,-6.29,;16.43,-5.66,;16.59,-4.13,;15.06,-4.13,;15.82,-2.81,;18.1,-3.81,;18.87,-5.15,;20.31,-9.5,;19.41,-10.75,;20.32,-12,;21.79,-11.51,;23.13,-12.29,;24.46,-11.51,;24.46,-9.96,;25.79,-9.18,;23.12,-9.19,;21.78,-9.97,)| Show InChI InChI=1S/C22H22FN5O4S/c23-12-5-13-14(7-25-19(13)24-6-12)20-26-16-9-33(31,32)8-15(16)21(28-20)27-18-11-3-1-10(2-4-11)17(18)22(29)30/h5-7,10-11,17-18H,1-4,8-9H2,(H,24,25)(H,29,30)(H,26,27,28)/t10?,11?,17-,18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
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