Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Presenilin-1' and Ligand = 'BDBM193025'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM193025 (US9193726, 13 | US9193726, 14) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CC3(C)CCC(O3)c3ccc(cc3)C(F)(F)F)CCn2c1=O Show InChI InChI=1S/C25H25F3N4O3/c1-16-13-31(15-29-16)19-7-8-20-22(33)30(11-12-32(20)23(19)34)14-24(2)10-9-21(35-24)17-3-5-18(6-4-17)25(26,27)28/h3-8,13,15,21H,9-12,14H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	236	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193025 (US9193726, 13 | US9193726, 14) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CC3(C)CCC(O3)c3ccc(cc3)C(F)(F)F)CCn2c1=O Show InChI InChI=1S/C25H25F3N4O3/c1-16-13-31(15-29-16)19-7-8-20-22(33)30(11-12-32(20)23(19)34)14-24(2)10-9-21(35-24)17-3-5-18(6-4-17)25(26,27)28/h3-8,13,15,21H,9-12,14H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.04E+3	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair