Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Presenilin-1' and Ligand = 'BDBM193038'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM193038 (US9193726, 26) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@H]1C[C@H](COc2ccc(F)cc2C(F)(F)F)C1 |wU:18.20,wD:20.23,(14.36,-6.96,;13.73,-5.55,;12.22,-5.23,;12.06,-3.7,;13.47,-3.07,;14.5,-4.22,;10.73,-2.93,;10.73,-1.39,;9.4,-.62,;8.06,-1.39,;6.73,-.62,;6.73,.92,;5.39,-1.39,;5.39,-2.93,;6.73,-3.7,;8.06,-2.93,;9.4,-3.7,;9.4,-5.24,;4.06,-.62,;2.57,-1.02,;2.17,.47,;.84,1.24,;-.49,.47,;-1.83,1.24,;-1.83,2.78,;-3.16,3.55,;-4.49,2.78,;-5.83,3.55,;-4.49,1.24,;-3.16,.47,;-3.16,-1.07,;-3.16,-2.61,;-4.7,-1.07,;-1.62,-1.07,;3.66,.87,)| Show InChI InChI=1S/C24H22F4N4O3/c1-14-11-30(13-29-14)19-3-4-20-23(34)31(6-7-32(20)22(19)33)17-8-15(9-17)12-35-21-5-2-16(25)10-18(21)24(26,27)28/h2-5,10-11,13,15,17H,6-9,12H2,1H3/t15-,17-	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	303	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
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