Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Presenilin-1' and Ligand = 'BDBM193049'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM193049 (US9193726, 37) Show SMILES CC(C)c1cc(O[C@@H]2CC[C@H]2N2CCn3c(ccc(-n4cnc(C)c4)c3=O)C2=O)ccc1Cl Show InChI InChI=1S/C25H27ClN4O3/c1-15(2)18-12-17(4-5-19(18)26)33-23-9-8-20(23)29-10-11-30-22(25(29)32)7-6-21(24(30)31)28-13-16(3)27-14-28/h4-7,12-15,20,23H,8-11H2,1-3H3/t20-,23-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	158	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
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