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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Presenilin-1' and Ligand = 'BDBM50218998'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Presenilin-1


(Homo sapiens (Human))		BDBM50218998
PNG
(CHEMBL56665)
Show SMILES [H][C@@](O)(C(=O)N1CCCC[C@H]1C(=O)N[C@@H](CC1CCCCC1)C(=O)N(C)CCCC)c1ccccc1
Show InChI InChI=1S/C28H43N3O4/c1-3-4-18-30(2)27(34)23(20-21-13-7-5-8-14-21)29-26(33)24-17-11-12-19-31(24)28(35)25(32)22-15-9-6-10-16-22/h6,9-10,15-16,21,23-25,32H,3-5,7-8,11-14,17-20H2,1-2H3,(H,29,33)/t23-,24-,25-/m0/s1
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UniProtKB/SwissProt

B.MOAD
antibodypedia
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PC cid
PC sid
UniChem

Similars
PubMed
n/an/a>2.50E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of gamma-secretase activity in H4 human neuroglioma cells by measuring amyloid beta production

Bioorg Med Chem Lett 14: 1917-21 (2004)


BindingDB Entry DOI: 10.7270/Q2TT4T4K
More data for this
Ligand-Target Pair