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Found 1 hit Enz. Inhib. hit(s) with Target = 'Presenilin-1' and Ligand = 'BDBM50476443'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Presenilin-1


(Homo sapiens (Human))		BDBM50476443
PNG
(CHEMBL392993)
Show SMILES [H][C@]1(CCC[C@H](COC(=O)N2CCC(CC2)N2CCCCC2)N1S(=O)(=O)c1ccc(Cl)cc1)c1ccccc1F
Show InChI InChI=1S/C29H37ClFN3O4S/c30-22-11-13-25(14-12-22)39(36,37)34-24(7-6-10-28(34)26-8-2-3-9-27(26)31)21-38-29(35)33-19-15-23(16-20-33)32-17-4-1-5-18-32/h2-3,8-9,11-14,23-24,28H,1,4-7,10,15-21H2/t24-,28+/m1/s1
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PC cid
PC sid
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Article
PubMed
n/an/a 8n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase-mediated amyloid-beta peptid aggregation

Bioorg Med Chem Lett 17: 57-62 (2007)


Article DOI: 10.1016/j.bmcl.2006.09.094
BindingDB Entry DOI: 10.7270/Q2ZP48WP
More data for this
Ligand-Target Pair