Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Presenilin-1' and Ligand = 'BDBM50478083'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM50478083 (CHEMBL270379) Show SMILES CC1(C)CCC(N(Cc2ccc(cc2)C(=O)NC2CC2)S(=O)(=O)c2ccc(Cl)cc2)C(=O)NC1 Show InChI InChI=1S/C25H30ClN3O4S/c1-25(2)14-13-22(24(31)27-16-25)29(34(32,33)21-11-7-19(26)8-12-21)15-17-3-5-18(6-4-17)23(30)28-20-9-10-20/h3-8,11-12,20,22H,9-10,13-16H2,1-2H3,(H,27,31)(H,28,30)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Inhibition of human gamma secretase in HEK293 cells assessed as reduction of amyloid beta level by ELISA				Bioorg Med Chem Lett 18: 304-8 (2008) Article DOI: 10.1016/j.bmcl.2007.10.074 BindingDB Entry DOI: 10.7270/Q2J105X3
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