Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Presenilin-1' and Ligand = 'BDBM50483266'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM50483266 (CHEMBL1643444) Show SMILES CC[C@H](N1CCCc2c(noc12)-c1ccc(c(OC)c1)-n1cnc(C)c1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C26H27FN4O2/c1-4-22(18-7-10-20(27)11-8-18)31-13-5-6-21-25(29-33-26(21)31)19-9-12-23(24(14-19)32-3)30-15-17(2)28-16-30/h7-12,14-16,22H,4-6,13H2,1-3H3/t22-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	875	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells by sandwich immunoassay				Bioorg Med Chem Lett 21: 664-9 (2011) Article DOI: 10.1016/j.bmcl.2010.12.012 BindingDB Entry DOI: 10.7270/Q2930X12
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