Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Presenilin-1' and Ligand = 'BDBM50483274'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM50483274 (CHEMBL1643422) Show SMILES COc1cc(ccc1-n1cnc(C)c1)-c1nnc2N(CCCn12)C(C1CC1)c1ccc(F)cc1 Show InChI InChI=1S/C26H27FN6O/c1-17-15-31(16-28-17)22-11-8-20(14-23(22)34-2)25-29-30-26-32(12-3-13-33(25)26)24(18-4-5-18)19-6-9-21(27)10-7-19/h6-11,14-16,18,24H,3-5,12-13H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.64E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells by sandwich immunoassay				Bioorg Med Chem Lett 21: 664-9 (2011) Article DOI: 10.1016/j.bmcl.2010.12.012 BindingDB Entry DOI: 10.7270/Q2930X12
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