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Found 1 hit Enz. Inhib. hit(s) with Target = 'Prolyl hydroxylase EGLN2' and Ligand = 'BDBM385710'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM385710
PNG
(4-(7-{[(3- fluorophenyl) methyl]amino}- [1,2,4]tri...)
Show SMILES Fc1cccc(CNc2cc(-c3ccc(cc3)C#N)n3ncnc3c2)c1
Show InChI InChI=1S/C20H14FN5/c21-17-3-1-2-15(8-17)12-23-18-9-19(26-20(10-18)24-13-25-26)16-6-4-14(11-22)5-7-16/h1-10,13,23H,12H2
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n/an/a 29n/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...

Bioorg Med Chem 16: 7424-8 (2008)


BindingDB Entry DOI: 10.7270/Q2QJ7KMD
More data for this
Ligand-Target Pair