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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Prolyl hydroxylase EGLN2' and Ligand = 'BDBM385722'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM385722
PNG
(2-fluoro-4-(7-{[(3- methyloxetan-3- yl)methyl]amin...)
Show SMILES CC1(CNc2cc(-c3ccc(C#N)c(F)c3)n3ncnc3c2)COC1
Show InChI InChI=1S/C18H16FN5O/c1-18(9-25-10-18)8-21-14-5-16(24-17(6-14)22-11-23-24)12-2-3-13(7-20)15(19)4-12/h2-6,11,21H,8-10H2,1H3
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n/an/a 47n/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...

Bioorg Med Chem 16: 7424-8 (2008)


BindingDB Entry DOI: 10.7270/Q2QJ7KMD
More data for this
Ligand-Target Pair