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Found 1 hit Enz. Inhib. hit(s) with Target = 'Prolyl hydroxylase EGLN2' and Ligand = 'BDBM385766'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM385766
PNG
(N-[5-(4-cyano-3- fluorophenyl)- [1,2,4]triazolo[1,...)
Show SMILES Fc1cc(ccc1C#N)-c1cc(NC(=O)CC2CC2)cc2ncnn12
Show InChI InChI=1S/C18H14FN5O/c19-15-6-12(3-4-13(15)9-20)16-7-14(8-17-21-10-22-24(16)17)23-18(25)5-11-1-2-11/h3-4,6-8,10-11H,1-2,5H2,(H,23,25)
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n/an/a 49n/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...

Bioorg Med Chem 16: 7424-8 (2008)


BindingDB Entry DOI: 10.7270/Q2QJ7KMD
More data for this
Ligand-Target Pair