Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostaglandin D2 receptor 2 (Homo sapiens (Human)) | BDBM17638 (2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Oxagen Ltd. Curated by ChEMBL | Assay Description In vitro binding affinity (agonistic) towards human CRTH2 receptor expressed in CHO cells; range 15 to 25 nM | J Med Chem 48: 6174-7 (2005) Article DOI: 10.1021/jm050519b BindingDB Entry DOI: 10.7270/Q2KK9B9B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin D2 receptor 2 (Homo sapiens (Human)) | BDBM17638 (2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Oxagen Ltd. Curated by ChEMBL | Assay Description Binding affinity towards human CRTH2 receptor expressed in CHO cells; range 25 nM to 8 uM | J Med Chem 48: 6174-7 (2005) Article DOI: 10.1021/jm050519b BindingDB Entry DOI: 10.7270/Q2KK9B9B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin D2 receptor 2 (Homo sapiens (Human)) | BDBM17638 (2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | n/a | 389 | n/a | n/a | n/a | n/a |
Oxagen Ltd. Curated by ChEMBL | Assay Description Partial antagonist activity at CRTH2 in human eosinophils assessed as inhibition of PGD2-induced shape change by FACS analysis | J Med Chem 55: 2915-31 (2012) Article DOI: 10.1021/jm2013997 BindingDB Entry DOI: 10.7270/Q2Z0398R | |||||||||||
More data for this Ligand-Target Pair |