Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50339185 ((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania Curated by ChEMBL | Assay Description Inhibition of COX1 in ram seminal vesicles using arachidonic acid as substrate assessed as reduction in PGH2 conversion to PGG2 by measuring TMPD oxi... | J Med Chem 59: 7431-44 (2016) Article DOI: 10.1021/acs.jmedchem.6b00160 BindingDB Entry DOI: 10.7270/Q21Z47WN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50339185 ((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description Inhibition of ovine COX-1 | J Med Chem 54: 1356-64 (2011) Article DOI: 10.1021/jm101403g BindingDB Entry DOI: 10.7270/Q2RJ4KFB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50339185 ((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by ChEMBL | Assay Description Inhibition of ovine COX1 | Bioorg Med Chem Lett 23: 163-8 (2012) Article DOI: 10.1016/j.bmcl.2012.10.131 BindingDB Entry DOI: 10.7270/Q26T0NZ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50339185 ((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Merck Pharmaceutical Company Curated by ChEMBL | Assay Description Tested for inhibitory activity against Prostaglandin G/H synthase 1 from ovine | J Med Chem 38: 3895-901 (1995) BindingDB Entry DOI: 10.7270/Q28C9WX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Homo sapiens (Human)) | BDBM50339185 ((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 8.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00878 BindingDB Entry DOI: 10.7270/Q2NV9P7Z | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Homo sapiens (Human)) | BDBM50339185 ((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer Curated by ChEMBL | Assay Description Inhibitory activity against prostaglandin G/H synthase 1 | J Med Chem 43: 214-23 (2000) BindingDB Entry DOI: 10.7270/Q2DV1KK0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Homo sapiens (Human)) | BDBM50339185 ((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Inhibition of COX1-catalyzed prostaglandin biosynthesis 10 mins of preincubation | J Nat Prod 61: 1212-5 (1998) Article DOI: 10.1021/np980088i BindingDB Entry DOI: 10.7270/Q26W9BZJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Bos taurus) | BDBM50339185 ((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Inhibition of bovine seminal microsomal COX1 assessed as PGE2 production preincubated for 10 mins | J Nat Prod 61: 2-7 (1998) Article DOI: 10.1021/np970343j BindingDB Entry DOI: 10.7270/Q2JS9RBH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50339185 ((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.13E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universitat de Barcelona Curated by ChEMBL | Assay Description Inhibition of ovine COX1 assessed as reduction in PGH2 production by enzyme immunoassay | Bioorg Med Chem 26: 4113-4126 (2018) Article DOI: 10.1016/j.bmc.2018.06.038 BindingDB Entry DOI: 10.7270/Q2S1855F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50339185 ((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.95E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexander Technological Education Institute of Thessaloniki Curated by ChEMBL | Assay Description Inhibition of ovine COX1 assessed as PGF2alpha production by enzyme immunoassay | Eur J Med Chem 47: 111-24 (2012) Article DOI: 10.1016/j.ejmech.2011.10.029 BindingDB Entry DOI: 10.7270/Q2K937ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50339185 ((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Inhibitory concentration against Prostaglandin H2 synthase 1 (PGHS-1) from ram seminal vesicle | J Med Chem 39: 3929-37 (1996) Article DOI: 10.1021/jm960415o BindingDB Entry DOI: 10.7270/Q29W0G4Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50339185 ((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Pharmaceutical Chemistry of Aristotle University of Thessaloniki Curated by ChEMBL | Assay Description Inhibition of ovine COX1 assessed as inhibition of PGF2a production by enzyme immunoassay | Bioorg Med Chem 21: 532-9 (2012) Article DOI: 10.1016/j.bmc.2012.10.046 BindingDB Entry DOI: 10.7270/Q2H41SRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50339185 ((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 5.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Michigan State University Curated by ChEMBL | Assay Description Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 3 mins followed by substrate addition measured immediately | J Nat Prod 80: 2472-2477 (2017) Article DOI: 10.1021/acs.jnatprod.7b00322 BindingDB Entry DOI: 10.7270/Q29Z97DR | |||||||||||
More data for this Ligand-Target Pair |