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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Proteasome subunit beta type-5' and Ligand = 'BDBM50426999'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50426999
PNG
(CHEMBL2326266)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C31H43N7O5S/c1-21(2)17-25(13-16-44(5,42)43)34-29(39)26(18-22(3)4)35-30(40)27(19-24-11-14-33-15-12-24)36-31(41)28(37-38-32)20-23-9-7-6-8-10-23/h6-16,21-22,25-28H,17-20H2,1-5H3,(H,34,39)(H,35,40)(H,36,41)/b16-13+/t25-,26+,27+,28+/m1/s1
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Article
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n/an/a 160n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome beta 5 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair