Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proteasome subunit beta type-9 (Homo sapiens (Human)) | BDBM50538161 (CHEMBL4646371) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human 20S proteasome LMP2 activity in human RPMI-8226 cells using Ac-PAL-AMC as fluorogenic substrate incubated for 72 hrs by fluoresce... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00291 BindingDB Entry DOI: 10.7270/Q2RX9GWM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit beta type-9 (Homo sapiens (Human)) | BDBM50538161 (CHEMBL4646371) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 103 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Inhibition of LMP2 in human 20S immunoproteasome using Ac-PAL-AMC as substrate after 1 hr by fluorescence based microplate reader analysis | J Med Chem 63: 3763-3783 (2020) Article DOI: 10.1021/acs.jmedchem.0c00416 BindingDB Entry DOI: 10.7270/Q2HH6PM2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit beta type-9 (Homo sapiens (Human)) | BDBM50538161 (CHEMBL4646371) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 105 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human 20S proteasome LMP2 using Ac-PAL-AMC as fluorogenic substrate measured every minute for 1 hr by fluorescence assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00291 BindingDB Entry DOI: 10.7270/Q2RX9GWM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit beta type-9 (Homo sapiens (Human)) | BDBM50538161 (CHEMBL4646371) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 213 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human 20S proteasome LMP2 activity in human RPMI-8226 cells overexpressing ABCB1 using Ac-PAL-AMC as fluorogenic substrate incubated fo... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00291 BindingDB Entry DOI: 10.7270/Q2RX9GWM | |||||||||||
More data for this Ligand-Target Pair |