BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'Protein Mdm4' and Ligand = 'BDBM50229787'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Protein Mdm4 (Homo sapiens (Human))	BDBM50229787 ((4S,5R)-Nutlin-3 \| (rac)-(4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB	6.90E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Tested for ability to inhibit human erythrocyte carbonic-anhydrase-II- (HCA II) catalyzed carbon dioxide hydration				Citation and Details
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein Mdm4 (Homo sapiens (Human))	BDBM50229787 ((4S,5R)-Nutlin-3 \| (rac)-(4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of human MDM4 by TR-FRET assay				J Med Chem 58: 6348-58 (2015) Article DOI: 10.1021/acs.jmedchem.5b00810 BindingDB Entry DOI: 10.7270/Q2HQ41QV
					More data for this Ligand-Target Pair				3D Structure (crystal)