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Found 1 hit Enz. Inhib. hit(s) with Target = 'Protein Tat' and Ligand = 'BDBM50048864'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein Tat


(Human immunodeficiency virus type 1 (isolate HXB2 ...)		BDBM50048864
PNG
(CHEMBL3310505)
Show SMILES [H][C@@]12CC(=O)N[C@H](C(C)C)C(=O)N[C@]([H])(CSSCC\C=C\1)C(=O)N\C(=C/C)C(=O)N[C@@H](C(C)C)C(=O)O2 |r,t:20|
Show InChI InChI=1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7+,16-6-/t15-,17+,19+,20-/m0/s1
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Article
PubMed
n/an/an/an/a 220n/an/an/an/a



The Walter and Eliza Hall Institute for Medical Research

Curated by ChEMBL


Assay Description
Activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells harboring LTR driven GFP reporter co-expressing CMV driven RFP reporter assessed as...

J Med Chem 62: 5148-5175 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00462
BindingDB Entry DOI: 10.7270/Q2FX7DW7
More data for this
Ligand-Target Pair