Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein cereblon (Homo sapiens (Human)) | BDBM7814 (Maleimide-Related Compound 13 | pyrrolidine-2,5-di...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 8.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence by MS... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00440 BindingDB Entry DOI: 10.7270/Q2WM1J1B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein cereblon (Homo sapiens (Human)) | BDBM7814 (Maleimide-Related Compound 13 | pyrrolidine-2,5-di...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 2.62E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute for Developmental Biology Curated by ChEMBL | Assay Description Inhibition of MANT-uracil binding to human CRBN (delta 1 to 315) by Cheng-Prusoff equation analysis | J Med Chem 59: 770-4 (2016) Article DOI: 10.1021/acs.jmedchem.5b01735 BindingDB Entry DOI: 10.7270/Q2PR7XVF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein cereblon (Homo sapiens (Human)) | BDBM7814 (Maleimide-Related Compound 13 | pyrrolidine-2,5-di...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence by MS... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00440 BindingDB Entry DOI: 10.7270/Q2WM1J1B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein cereblon (Homo sapiens (Human)) | BDBM7814 (Maleimide-Related Compound 13 | pyrrolidine-2,5-di...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.45E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute for Developmental Biology Curated by ChEMBL | Assay Description Inhibition of MANT-uracil binding to human CRBN (delta 1 to 315) by FRET assay | J Med Chem 59: 770-4 (2016) Article DOI: 10.1021/acs.jmedchem.5b01735 BindingDB Entry DOI: 10.7270/Q2PR7XVF | |||||||||||
More data for this Ligand-Target Pair |