Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM14424'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14424 (3-(2H-1,3-benzodioxol-5-yl)-5-[(4-chlorophenyl)(hy...) Show SMILES Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)n(-c3ccc4OCOc4c3)c2c1 Show InChI InChI=1S/C26H21ClN4O4/c1-29-14-28-13-24(29)26(33,16-3-6-18(27)7-4-16)17-5-9-20-21(11-17)31(25(32)30(20)2)19-8-10-22-23(12-19)35-15-34-22/h3-14,33H,15H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
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