Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine)) | BDBM14434 (6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 0.650 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Abbott Laboratories | Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r... | Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine)) | BDBM14434 (6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 0.650 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Abbott Laboratories | Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r... | Bioorg Med Chem Lett 15: 2033-9 (2005) Article DOI: 10.1016/j.bmcl.2005.02.062 BindingDB Entry DOI: 10.7270/Q23J3B61 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM14434 (6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 0.860 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Janssen Research Foundation | Assay Description Compounds were tested as inhibitors of FTase in vitro using purified human enzyme to catalyze the reaction between [3H] FPP and a biotinylated peptid... | Cancer Res 61: 131-7 (2001) BindingDB Entry DOI: 10.7270/Q20C4T2R | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM14434 (6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Janssen Research Foundation | Assay Description Compounds were tested as inhibitors of FTase in vitro using purified human enzyme to catalyze the reaction between [3H] FPP and a biotinylated peptid... | Cancer Res 61: 131-7 (2001) BindingDB Entry DOI: 10.7270/Q20C4T2R | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |