Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM14440'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14440 (4-[(1-{[5-(3-chlorophenyl)-8-methyl-7-oxo-7,8-dihy...) Show SMILES Cn1c2ncc(Cn3cncc3Cc3ccc(cc3)C#N)cc2c(cc1=O)-c1cccc(Cl)c1 Show InChI InChI=1S/C27H20ClN5O/c1-32-26(34)12-24(21-3-2-4-22(28)11-21)25-10-20(14-31-27(25)32)16-33-17-30-15-23(33)9-18-5-7-19(13-29)8-6-18/h2-8,10-12,14-15,17H,9,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2033-9 (2005) Article DOI: 10.1016/j.bmcl.2005.02.062 BindingDB Entry DOI: 10.7270/Q23J3B61
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