Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM14449'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14449 (2-quinolone analog 25b | 4-(3-chlorophenyl)-1-meth...) Show SMILES Cn1c2ccc(Cn3cncc3Cn3ccc(c3)C(=O)N3CCOCC3)cc2c(cc1=O)-c1cccc(Cl)c1 Show InChI InChI=1S/C30H28ClN5O3/c1-33-28-6-5-21(13-27(28)26(15-29(33)37)22-3-2-4-24(31)14-22)17-36-20-32-16-25(36)19-34-8-7-23(18-34)30(38)35-9-11-39-12-10-35/h2-8,13-16,18,20H,9-12,17,19H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2033-9 (2005) Article DOI: 10.1016/j.bmcl.2005.02.062 BindingDB Entry DOI: 10.7270/Q23J3B61
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