Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM14452'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14452 (4-[(5-{[5-(naphthalen-1-yl)-1H-indol-1-yl]methyl}-...) Show SMILES N#Cc1ccc(Cn2cncc2Cn2ccc3cc(ccc23)-c2cccc3ccccc23)cc1 Show InChI InChI=1S/C30H22N4/c31-17-22-8-10-23(11-9-22)19-34-21-32-18-27(34)20-33-15-14-26-16-25(12-13-30(26)33)29-7-3-5-24-4-1-2-6-28(24)29/h1-16,18,21H,19-20H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.930	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2033-9 (2005) Article DOI: 10.1016/j.bmcl.2005.02.062 BindingDB Entry DOI: 10.7270/Q23J3B61
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