Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM50076803'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076803 (CHEMBL10970 | Lithium; (S)-2-({5-[5-(2-fluoro-phen...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccccc2F)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C31H30FNO5S/c1-20-7-3-4-8-23(20)26-17-21(11-13-24(26)30(34)33-28(31(35)36)15-16-39-2)18-37-19-22-12-14-29(38-22)25-9-5-6-10-27(25)32/h3-14,17,28H,15-16,18-19H2,1-2H3,(H,33,34)(H,35,36)/p-1/t28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50076803 (CHEMBL10970 | Lithium; (S)-2-({5-[5-(2-fluoro-phen...) Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccccc2F)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C31H30FNO5S/c1-20-7-3-4-8-23(20)26-17-21(11-13-24(26)30(34)33-28(31(35)36)15-16-39-2)18-37-19-22-12-14-29(38-22)25-9-5-6-10-27(25)32/h3-14,17,28H,15-16,18-19H2,1-2H3,(H,33,34)(H,35,36)/p-1/t28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	>1	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)				Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT
					More data for this Ligand-Target Pair