Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM50079677'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50079677 ((S)-2-[3-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmet...) Show SMILES COC(=O)[C@H](CCSC)NC(=O)c1cccc(CNCc2cncn2Cc2ccc(cc2)C#N)c1 Show InChI InChI=1S/C26H29N5O3S/c1-34-26(33)24(10-11-35-2)30-25(32)22-5-3-4-21(12-22)14-28-15-23-16-29-18-31(23)17-20-8-6-19(13-27)7-9-20/h3-9,12,16,18,24,28H,10-11,14-15,17H2,1-2H3,(H,30,32)/t24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Reduction in the FTase-catalyzed (enzyme purified from bovine brain) incorporation of [3H]-FPP into recombinant Ha-Ras.				Bioorg Med Chem Lett 9: 1991-6 (1999) BindingDB Entry DOI: 10.7270/Q2ZG6RFB
					More data for this Ligand-Target Pair