Found 6 hits Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM50098002' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098002
(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1c(-c2ccccc2)n(C)c2ccccc12 Show InChI InChI=1S/C26H27N3O/c1-19(2)29(18-20-13-15-27-16-14-20)25(30)17-23-22-11-7-8-12-24(22)28(3)26(23)21-9-5-4-6-10-21/h4-16,19H,17-18H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for the inhibitory activity against human Farnesyltransferase |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098002
(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1c(-c2ccccc2)n(C)c2ccccc12 Show InChI InChI=1S/C26H27N3O/c1-19(2)29(18-20-13-15-27-16-14-20)25(30)17-23-22-11-7-8-12-24(22)28(3)26(23)21-9-5-4-6-10-21/h4-16,19H,17-18H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of K-Ras farnesylation in PSN-1 cells with 100 nM GGT1 |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098002
(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1c(-c2ccccc2)n(C)c2ccccc12 Show InChI InChI=1S/C26H27N3O/c1-19(2)29(18-20-13-15-27-16-14-20)25(30)17-23-22-11-7-8-12-24(22)28(3)26(23)21-9-5-4-6-10-21/h4-16,19H,17-18H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of HDJ-2 farnesylation in PSN-1 cells with 100 nM GGT1 |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098002
(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1c(-c2ccccc2)n(C)c2ccccc12 Show InChI InChI=1S/C26H27N3O/c1-19(2)29(18-20-13-15-27-16-14-20)25(30)17-23-22-11-7-8-12-24(22)28(3)26(23)21-9-5-4-6-10-21/h4-16,19H,17-18H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 1.33E+3 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of HDJ-2 farnesylation in PSN-1 cells |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098002
(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1c(-c2ccccc2)n(C)c2ccccc12 Show InChI InChI=1S/C26H27N3O/c1-19(2)29(18-20-13-15-27-16-14-20)25(30)17-23-22-11-7-8-12-24(22)28(3)26(23)21-9-5-4-6-10-21/h4-16,19H,17-18H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of K-Ras farnesylation in PSN-1 cells without GGT1 |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50098002
(CHEMBL355551 | N-Isopropyl-2-(1-methyl-2-phenyl-1H...)Show SMILES CC(C)N(Cc1ccncc1)C(=O)Cc1c(-c2ccccc2)n(C)c2ccccc12 Show InChI InChI=1S/C26H27N3O/c1-19(2)29(18-20-13-15-27-16-14-20)25(30)17-23-22-11-7-8-12-24(22)28(3)26(23)21-9-5-4-6-10-21/h4-16,19H,17-18H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 1.98E+3 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of HDJ-2 farnesylation in PSN-1 cells at without GGT1 |
Bioorg Med Chem Lett 11: 865-9 (2001)
BindingDB Entry DOI: 10.7270/Q2F47PPX |
More data for this
Ligand-Target Pair | |
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