Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM50109872'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50109872 (4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohep...) Show SMILES [#8-]-[n+]1ccc(-[#6]-[#7]-[#6](=[#7]C#N)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2/c3ccc(Cl)cc3-[#6]-[#6]-c3cc(Br)cnc-23)cc1 |w:8.8| Show InChI InChI=1S/C27H24BrClN6O/c28-22-13-21-2-1-20-14-23(29)3-4-24(20)25(26(21)31-16-22)19-7-9-34(10-8-19)27(33-17-30)32-15-18-5-11-35(36)12-6-18/h3-6,11-14,16H,1-2,7-10,15H2,(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description FPT inhibitory activity was determined by the ability of the compound to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-ras-C...				Bioorg Med Chem Lett 12: 601-5 (2002) BindingDB Entry DOI: 10.7270/Q2FF3RPB
					More data for this Ligand-Target Pair