BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM50126041'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50126041 (6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.370	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human FTase-catalyzed incorporation of [3H]FPP into recombinant Ras CVIM				Bioorg Med Chem Lett 13: 1293-6 (2003) BindingDB Entry DOI: 10.7270/Q2DV1J8J
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50126041 (6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.370	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIM				Bioorg Med Chem Lett 13: 1293-6 (2003) BindingDB Entry DOI: 10.7270/Q2DV1J8J
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus)	BDBM50126041 (6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.74	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Reduced farnesylation in H-Ras NIH3T3 cells				Bioorg Med Chem Lett 14: 5057-62 (2004) Article DOI: 10.1016/j.bmcl.2004.07.083 BindingDB Entry DOI: 10.7270/Q2N0160C
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50126041 (6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	2.70	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of farnesylation in NIH-3T3H-ras cell line				Bioorg Med Chem Lett 13: 1293-6 (2003) BindingDB Entry DOI: 10.7270/Q2DV1J8J
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50126041 (6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	2.70	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIM				Bioorg Med Chem Lett 13: 1293-6 (2003) BindingDB Entry DOI: 10.7270/Q2DV1J8J
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair