Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50327991 (1-methyl-1H-imidazole-4-sulfonic acid {2-[(4-cyano...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University Curated by ChEMBL | Assay Description Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLS | J Med Chem 53: 6867-88 (2010) Article DOI: 10.1021/jm1001748 BindingDB Entry DOI: 10.7270/Q26110JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Mus musculus) | BDBM50327991 (1-methyl-1H-imidazole-4-sulfonic acid {2-[(4-cyano...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University Curated by ChEMBL | Assay Description Inhibition of H-Ras-mediated farnesylation expressed in mouse NIH3T3 cells | J Med Chem 53: 6867-88 (2010) Article DOI: 10.1021/jm1001748 BindingDB Entry DOI: 10.7270/Q26110JC | |||||||||||
More data for this Ligand-Target Pair |