BindingDB PrimarySearch

Found 4 hits Enz. Inhib. hit(s) with Target = 'Protein-lysine 6-oxidase' and Ligand = 'BDBM50232678'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Protein-lysine 6-oxidase (Homo sapiens (Human))	BDBM50232678 (CHEBI:27413 \| CHEMBL1618272 \| US10717734, Compound...) Show SMILES NCCC#N Show InChI InChI=1S/C3H6N2/c4-2-1-3-5/h1-2,4H2	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
PharmAkea Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human LOX expressed in HEK cells assessed as reduction in H2O2 production using DAP as substrate preincubated f...				ACS Med Chem Lett 8: 423-427 (2017) Article DOI: 10.1021/acsmedchemlett.7b00014 BindingDB Entry DOI: 10.7270/Q2542QV6
PharmAkea Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Protein-lysine 6-oxidase (Homo sapiens (Human))	BDBM50232678 (CHEBI:27413 \| CHEMBL1618272 \| US10717734, Compound...) Show SMILES NCCC#N Show InChI InChI=1S/C3H6N2/c4-2-1-3-5/h1-2,4H2	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
PharmAkea Therapeutics Curated by ChEMBL					Assay Description Inhibition of human LOX expressed in HEK cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs foll...				J Med Chem 60: 4403-4423 (2017) Article DOI: 10.1021/acs.jmedchem.7b00345 BindingDB Entry DOI: 10.7270/Q2QV3Q0K
PharmAkea Therapeutics Curated by ChEMBL					More data for this Ligand-Target Pair
Protein-lysine 6-oxidase (Bos taurus)	BDBM50232678 (CHEBI:27413 \| CHEMBL1618272 \| US10717734, Compound...) Show SMILES NCCC#N Show InChI InChI=1S/C3H6N2/c4-2-1-3-5/h1-2,4H2	MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaxis Ltd Curated by ChEMBL					Assay Description Inhibition of LOX in bovine aorta using putrescine as substrate preincubated with enzyme for 30 mins followed by substrate addition and measured ever...				J Med Chem 62: 9874-9889 (2019) Article DOI: 10.1021/acs.jmedchem.9b01283 BindingDB Entry DOI: 10.7270/Q2VM4GJ2
Pharmaxis Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Protein-lysine 6-oxidase (Homo sapiens (Human))	BDBM50232678 (CHEBI:27413 \| CHEMBL1618272 \| US10717734, Compound...) Show SMILES NCCC#N Show InChI InChI=1S/C3H6N2/c4-2-1-3-5/h1-2,4H2	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Hungarian Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of recombinant human LOX expressed in HEK293 cells using diaminopentane as substrate preincubated for 30 mins followed by substrate additi...				Bioorg Med Chem Lett 28: 3113-3118 (2018) Article DOI: 10.1016/j.bmcl.2018.07.001 BindingDB Entry DOI: 10.7270/Q28P6366
Hungarian Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair