Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Prothrombin' and Ligand = 'BDBM17109'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prothrombin (Homo sapiens (Human))	BDBM17109 (3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carb...) Show SMILES COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)C(=O)NCCN2CCCC2)c1Cl Show InChI InChI=1S/C27H29Cl3N6O4S/c1-35(27(39)31-7-10-36-8-3-4-9-36)14-16-15-41-24(22(16)30)26(38)34-23-19(11-18(29)12-20(23)40-2)25(37)33-21-6-5-17(28)13-32-21/h5-6,11-13,15H,3-4,7-10,14H2,1-2H3,(H,31,39)(H,34,38)(H,32,33,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences					Assay Description The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...				J Med Chem 50: 2967-80 (2007) Article DOI: 10.1021/jm070125f BindingDB Entry DOI: 10.7270/Q2J101F5
					More data for this Ligand-Target Pair