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Found 1 hit Enz. Inhib. hit(s) with Target = 'Prothrombin' and Ligand = 'BDBM50216992'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prothrombin


(Homo sapiens (Human))		BDBM50216992
PNG
(CHEMBL98859)
Show SMILES Cc1cnc(NCCc2ccc(F)cc2)c(=O)n1CC(=O)NCc1ccc2c(N)noc2c1
Show InChI InChI=1S/C23H23FN6O3/c1-14-11-28-22(26-9-8-15-2-5-17(24)6-3-15)23(32)30(14)13-20(31)27-12-16-4-7-18-19(10-16)33-29-21(18)25/h2-7,10-11H,8-9,12-13H2,1H3,(H2,25,29)(H,26,28)(H,27,31)
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PubMed
 18n/an/an/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human Thrombin (FIIa) cleavage of the chromogenic substrate

Bioorg Med Chem Lett 12: 2925-30 (2002)


BindingDB Entry DOI: 10.7270/Q27946WJ
More data for this
Ligand-Target Pair