Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Proto-oncogene Wnt-3' and Ligand = 'BDBM50265582'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene Wnt-3 (Homo sapiens (Human))	BDBM50265582 (CHEMBL496581 | N-[1-(1-Methyl-L-prolyl)piperidin-4...) Show SMILES CN1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 |r| Show InChI InChI=1S/C24H28F3N3O5S2/c1-29-13-5-8-21(29)23(31)30-14-11-17(12-15-30)28-37(34,35)22-16-19(9-10-20(22)24(25,26)27)36(32,33)18-6-3-2-4-7-18/h2-4,6-7,9-10,16-17,21,28H,5,8,11-15H2,1H3/t21-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	230	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay				J Med Chem 52: 105-16 (2009) Article DOI: 10.1021/jm801144h BindingDB Entry DOI: 10.7270/Q2NZ87HT
					More data for this Ligand-Target Pair