Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret' and Ligand = 'BDBM367715'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM367715 (US10227329, Compound 127) Show SMILES Cc1cc(Nc2cc(C)cc(n2)N2CCC(C)(CC2)C(=O)NCc2ccc(nc2)-n2cccn2)n[nH]1 Show InChI InChI=1S/C26H31N9O/c1-18-13-21(30-22-15-19(2)32-33-22)31-24(14-18)34-11-7-26(3,8-12-34)25(36)28-17-20-5-6-23(27-16-20)35-10-4-9-29-35/h4-6,9-10,13-16H,7-8,11-12,17H2,1-3H3,(H,28,36)(H2,30,31,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				J Med Chem 51: 1231-41 (2008) BindingDB Entry DOI: 10.7270/Q22V2JDM
					More data for this Ligand-Target Pair