Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret' and Ligand = 'BDBM367772'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM367772 (US10227329, Compound 184) Show SMILES COC1(CN(C1)c1nc(Nc2cc(C)[nH]n2)cc(C)c1C#N)C(=O)NCc1ccc(nc1)-n1cc(F)cn1 Show InChI InChI=1S/C25H25FN10O2/c1-15-6-20(31-21-7-16(2)33-34-21)32-23(19(15)8-27)35-13-25(14-35,38-3)24(37)29-10-17-4-5-22(28-9-17)36-12-18(26)11-30-36/h4-7,9,11-12H,10,13-14H2,1-3H3,(H,29,37)(H2,31,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				J Med Chem 51: 1231-41 (2008) BindingDB Entry DOI: 10.7270/Q22V2JDM
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