Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret' and Ligand = 'BDBM50448814'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50448814 (CHEMBL3128224) Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1cccc(CNc2ncnc3n(CCc4ccccc4)ncc23)c1 Show InChI InChI=1S/C27H26N6O3S/c1-36-23-10-12-24(13-11-23)37(34,35)32-22-9-5-8-21(16-22)17-28-26-25-18-31-33(27(25)30-19-29-26)15-14-20-6-3-2-4-7-20/h2-13,16,18-19,32H,14-15,17H2,1H3,(H,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.72E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of recombinant human RET incubated for 5 mins with substrate prior to protein addition by fluorescence assay				J Med Chem 57: 1225-35 (2014) Article DOI: 10.1021/jm401358b BindingDB Entry DOI: 10.7270/Q2X34ZZP
					More data for this Ligand-Target Pair