Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret' and Ligand = 'BDBM50448817'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50448817 (CHEMBL3128220) Show SMILES O=S(=O)(Nc1cccc(CNc2ncnc3n(CCc4ccccc4)ncc23)c1)c1ccccc1 Show InChI InChI=1S/C26H24N6O2S/c33-35(34,23-12-5-2-6-13-23)31-22-11-7-10-21(16-22)17-27-25-24-18-30-32(26(24)29-19-28-25)15-14-20-8-3-1-4-9-20/h1-13,16,18-19,31H,14-15,17H2,(H,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of recombinant human RET incubated for 5 mins with substrate prior to protein addition by fluorescence assay				J Med Chem 57: 1225-35 (2014) Article DOI: 10.1021/jm401358b BindingDB Entry DOI: 10.7270/Q2X34ZZP
					More data for this Ligand-Target Pair