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Found 1 hit Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,G810R]' and Ligand = 'BDBM296777'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,G810R]


(Homo sapiens (Human))		BDBM296777
PNG
(6-ethoxy-4-(6-(1-((4- methoxyphenyl) sulfonyl)-1,6...)
Show SMILES CCOc1cc(-c2ccc(nc2)N2CCC3(CN3S(=O)(=O)c3ccc(OC)cc3)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H28N6O4S/c1-3-38-23-14-25(27-21(15-29)17-31-33(27)18-23)20-4-9-26(30-16-20)32-12-10-28(11-13-32)19-34(28)39(35,36)24-7-5-22(37-2)6-8-24/h4-9,14,16-18H,3,10-13,19H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 380n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The potency of a compound inhibiting G81 OR mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays containe...

US Patent US10555944 (2020)


BindingDB Entry DOI: 10.7270/Q279473N
More data for this
Ligand-Target Pair