Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,G810R]' and Ligand = 'BDBM296788'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,G810R] (Homo sapiens (Human))	BDBM296788 (US10112942, Example 523 | US10137124, Example 523 ...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CC[C@@]3(C2)CCCNC3)c2c(cnn2c1)C#N |r| Show InChI InChI=1S/C23H26N6O/c1-2-30-19-10-20(22-18(11-24)13-27-29(22)14-19)17-4-5-21(26-12-17)28-9-7-23(16-28)6-3-8-25-15-23/h4-5,10,12-14,25H,2-3,6-9,15-16H2,1H3/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	473	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The potency of a compound inhibiting G81 OR mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays containe...				US Patent US10555944 (2020) BindingDB Entry DOI: 10.7270/Q279473N
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