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Found 1 hit Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,G810R]' and Ligand = 'BDBM296824'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,G810R]


(Homo sapiens (Human))		BDBM296824
PNG
(6-ethoxy-4-(5-(6-((6- methoxy-5- methylpyridin-3- ...)
Show SMILES CCOc1cc(-c2cnc(cn2)N2CC3CC(C2)N3Cc2cnc(OC)c(C)c2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C27H28N8O2/c1-4-37-22-7-23(26-19(8-28)10-32-35(26)16-22)24-11-30-25(12-29-24)33-14-20-6-21(15-33)34(20)13-18-5-17(2)27(36-3)31-9-18/h5,7,9-12,16,20-21H,4,6,13-15H2,1-3H3
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 302n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The potency of a compound inhibiting G81 OR mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays containe...

US Patent US10555944 (2020)


BindingDB Entry DOI: 10.7270/Q279473N
More data for this
Ligand-Target Pair