Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M] (Homo sapiens (Human)) | BDBM296748 (US10112942, Example 483 | US10137124, Example 483 ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 28.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc. US Patent | Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech... | US Patent US10172851 (2019) BindingDB Entry DOI: 10.7270/Q2GM89CV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M] (Homo sapiens (Human)) | BDBM296748 (US10112942, Example 483 | US10137124, Example 483 ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 28.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Array Biopharma Inc. US Patent | Assay Description RET: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE™-TK assa... | US Patent US10953005 (2021) BindingDB Entry DOI: 10.7270/Q2668H9T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M] (Homo sapiens (Human)) | BDBM296748 (US10112942, Example 483 | US10137124, Example 483 ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 28.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company US Patent | Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn... | US Patent US10555944 (2020) BindingDB Entry DOI: 10.7270/Q279473N | |||||||||||
More data for this Ligand-Target Pair |